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Foot and Mouth Disease Vaccine Production - FMDVP


The Livestock & Fisheries Department intends to establish FMD vaccine production unit project under PPP modality.

Pakistan is endowed with a large livestock population. Productivity of livestock in Pakistan is generally low. One of the main reasons of low productivity is frequent occurrence of infectious diseases particularly Foot-and-mouth disease (FMD). The FMD is a highly contagious viral disease that affects mainly cloven-hoofed animals (i.e. buffaloes, cows, sheep, goats, pigs). Its symptoms include fever, blisters in the mouth, lesions on the feet which can cause lameness, weight loss and a drop in milk production. The FMD is a severe plague for animal farming, since it is highly infectious and can be spread by infected animals through aerosols, through contact with contaminated farming equipment, vehicles, clothing or feed, by domestic and wild predators and by escape through research and vaccine production laboratories. Its containment demands considerable efforts in vaccination, strict monitoring, trade restrictions and quarantines, and occasionally the elimination of millions of animals.

In developed countries, the FMD infected animal is burned or culled to control FMD, however, in developing countries such as Pakistan, vaccination is the only option. The best and proven way to control the FMD is by effective mass vaccination. Currently, Pakistan is importing FAO recognized FMD vaccine produced at Russia and from Turkey. FMD Vaccines are only applied to healthy animals to prevent them from that specific upcoming disease. At least 2 doses of FMD are required per animal per annum. But where there is more prevalent infection like in cattle colonies the doses sometimes are 4 per annum required. Vaccines are only applied to healthy animals to prevent them from upcoming disease.

The per dose price of imported vaccine is quite high and is un-affordable for subsistent farmers. Secondly, the FMD vaccine is imported in low quantities which cannot cater to whole of the animal population. Furthermore, the imported vaccine is sometimes ineffective to local veterinary animals due to difference antigenic properties of disease causing agent as compared to the vaccine exporting country. Therefore, Pakistan need to have custom-made FMD vaccine for application to local animals, within Pakistan.

Neighboring countries of Pakistan i.e. China, Turkey and India established FMD vaccination manufacturing plants in 1970s, whereas Iran established such facility in 1980s. Unfortunately, Pakistan has not established even a single FMD vaccine manufacturing plant at commercial scale over 70 years-period.

The Sindh province has competitive advantage for establishing FMD vaccine manufacturing plant due to following factors:

  • Karachi is the economic hub of the country having sea, land and airports connected internationally with major transit routes of Africa, Europe and Asia. Furthermore, Karachi harbors millions of buffaloes at Landhi cattle colony, Khawaja Bhains colony and large scale private farms.
  • Historically there have been reports of FMD outbreaks associated with the use and manufacture of FMD vaccines & research when activity is performed on mainland. Consequently, there is global trend of shifting FMD vaccination production facilities to islands. The Sindh province has more than 30 small islands within the range of 50 km of radius at coastal area of Karachi adjoining Thatta.
  • The significance of establishing such facility at island can be gauged from the fact that once due to extensive vaccination when country is declared FMD free, the facility handling FMD virus on mainland needs to be shut-down. Whereas, facility on island may continue to produce FMD vaccine and can earn foreign exchange by export of the same.
  • Sindh Institute of Animal Health Karachi erstwhile Sindh Poultry Vaccine Centre is the largest vaccine production centre of Pakistan established in 1974 through USAID, FAO and UNDP funding by the Government of Sindh is pioneer in viral vaccine production. It is backed by legal framework through passage of provincial legislation in 2018 and has been re-mandated for vaccine production in Sindh as well as supply throughout country, whereas as all other veterinary institutes of country may lack such legal framework and mandate.
  • Strong Public Private Partnership (PPP) framework of Sindh has gained great credibility of international multilateral institutions and ranked 6th in Asia by The Economist survey in 2018. The Sindh province has implemented successfully array of projects in road, bridges, health and education sector to name the few.


The PPP Policy Board in its 29th meeting held on 20th July 2019 approved the Project.


The Livestock & Fisheries Department has initiated procurement process to engage transaction advisors. It is expected that transaction advisors shall be engaged by November 2021.


Livestock & Fisheries Department



Project Related DocumentsUploaded on
Response to Prospective Bidders Queries and Addendum to the Request for Proposal 01-06-2021

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